Does normal developmental expression of psychosis combine. Highpotency cannabis and the risk of psychosis article pdf available in the british journal of psychiatry. Method sample we approached all patients aged 1865 years who presented with a first episode of psychosis to the lambeth, southwark and croydon. Cannabis use and transition to psychosis in individuals at ultra high.
Evidence compatible with this latter suggestion comes from our previous work showing that frequency of cannabis use is important in determining risk of psychosis, and that use of high potency types of cannabis such as skunk carries a higher risk of psychosis. Evidence for a relationship between cannabis use and risk for psychosis has been replicated frequently. This risk increases to almost threefold when individuals use high potency cannabis skunk 7, which is suggestive of a doseresponse effect. Psychotic disorders are severe mental health condition and theres consistent evidence showing a link between heavy or repeated cannabis use and an experience of psychosis for the first time. Gwas of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. This is a pdf file of an unedited manuscript that has been accepted for publication. An analysis of results from 35 studies revealed a pooled odds ratio of 1.
Cannabis is the most widely used illicit drug in the uk and previous research has suggested an association between use of the drug and psychosis, however the causal direction and underlying. People who use cannabis have an increased risk of psychosis, an effect attributed to the active ingredient. Highpotency cannabis and the risk of psychosis the. Importantly, everyday use of highpotency cannabis further increased the risk of psychotic disorder. With mounting evidence that the risk of cannabis induced psychosis may be related to both dose and potency of tetrahydrocannbinol thc, increasing reports of psychosis associated with. Thc is the primary psychoactive compound, with cbd, a nonpsychoactive. Association between cannabis and psychosis explore bristol. We then focus on cannabis use and risk of psychiatric disorder, particularly psychosis, before touching on the effects on cog nition and brain structure. There was an odds ratio of almost four for risk of psychosis. The finding that people with a first episode of psychosis had smoked higherpotency cannabis, for longer and with greater frequency, than a healthy control group is consistent with the hypothesis that. Highpotency cannabis and the risk of psychosis ncbi. Daily use, especially of highpotency cannabis, drives the.
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